Spectrum: Clinical Decision Support for Infectious Disease, for BC Women's Hospital
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Trimethoprim

Dosing

Neonatal

Urinary tract infection prophylaxis in infants with ureteric reflux or a structural renal tract abnormality:
0.5 - 1 mg/kg/dose PO Q24H

Renal

Reduce dose by 50% in infants with mild to moderate renal dysfunction. Avoid in infants with severe renal failure

General Information

Drug Monitoring

Neonatal: Obtain CBC, platelet count, liver enzymes, bilirubin, creatinine, urea periodically during prolonged therapy

Adverse Effects

Neonatal:

  • Fever

  • Rash

  • Exfoliative dermatitis

  • Increased liver enzymes

  • Cholestatic jaundice

  • Nausea/vomiting

  • Bone marrow suppression with prolonged treatment (rare)

Major Interactions

Neonatal: Increases serum levels of phenytoin, rifampin, procainamide and warfarin

Supplied Forms/Strengths

Neonatal:
PO: 10 mg/mL oral suspension (compounded by Pharmacy)

Pharmacology

Route of Elimination: Eliminated mostly unchanged by kidney