875/125 mg PO BID or 500/125 mg PO TID
<10 eGFR10 - 30 eGFR30+ eGFR250 - 500 mg amoxicillin component daily - BID (do not use 875 mg tablet, if eGFR <30)250 - 500 mg amoxicillin component po BID (do not use 875 mg tablet if eGFR <30)875 mg PO BID or 500 mg PO TID of the amoxicillin component
Prophylaxis/treatment of bite wounds
Polymicrobial infections of the respiratory tract or abdomen
Skin and soft tissue infections
Pregnancy: Amoxicillin/clavulanic acid may be associated with NEC in the newborn if given near delivery in the setting of PPROM
For prolonged therapy monitor liver enzymes, CBC
Gastrointestinal side effects - diarrhea
Hepatotoxicity due to clavulanate - usually mild, liver failure is rare
Allergy/rash (immediate or delayed), cytopenias
Contraindicated in patients with true penicillin allergies.
Amoxicillin shares a common structural side chain with cephalexin, therefore, there is an increased risk of allergy cross reactivity between this agents.
Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor