Cefazolin

C difficile risk
Medium
Oral Bioavailability
N/A

Dosing

2 g IV q8h

For patients with a true allergy to penicillins (including a history of anaphylaxis)2 g IV x 1 dose THEN 1 g IV q8h until delivery

Weight < 120 kgWeight > 120 kg2 g IV x 1 dose 30 minutes prior to skin incision
Re-dose if procedure lasts > 4 hours or if patient loses > 1500 mL blood 3 g IV x 1 dose 30 minutes prior to skin incision
Re-dose if procedure lasts > 4 hours or if patient loses > 1500 mL blood

<1200g1200 to 2000g>2000gAge >28 DaysAge 0 to 4 weeks: 20 mg/kg/dose IV Q12HAge 0-7 days: 20 mg/kg/dose IV Q12H
Age >7 days: 20 mg/kg/dose IV Q12HAge 0-7 days: 20 mg/kg/dose IV Q12H
Age >7 days: 20 mg/kg/dose IV Q8HAll Infants: 20 mg/kg/dose IV Q8H

Age 0-7 DaysAge >7 Days30 mg/kg/dose IV Q12H x 4 doses30 mg/kg/dose IV Q8H x 6 doses

IV, IM

100 mg/mL

24H Refrigerate

0 - 30 30 - 50 50+ 2 g IV q12 - 24h2 g IV q12h2 g IV q8h

Increase dosing interval in renal impairment

General Information

  • Susceptible Staphylococcal, Streptococcal and Gram negative infections.

  • Skin and soft tissue infection (i.e. cellulitis), bone and joint infections, endocarditis

  • Surgical prophylaxis including cesarean section prophylaxis.

  • Chorioamnionitis and endometritis (in combination with metronidazole)

Pregnancy: Compatible.

Breastfeeding: Compatible.

  • Allergy (immediate or delayed).

  • Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.

Probenecid prolongs half-life. Drug interaction has been used therapeutically to give once daily cefazolin.

Cefazolin does not share any structural side chain similarities with any other beta lactam antibiotic including other cephalosporins.

  • Patients with true allergies to penicillin and other cephalosporins can receive cefazolin.

Cefazolin should be avoided in patients with a direct allergy to cefazolin itself or a history of severe Type IV hypersensitivity reactions (ie. Stevens Johnson Syndrome) to any beta lactam.

Antimicrobial class: 1st Generation Cephalosporin