2 g IV q8h
For patients with a true allergy to penicillins (including a history of anaphylaxis)2 g IV x 1 dose THEN 1 g IV q8h until delivery
Weight < 120 kgWeight > 120 kg2 g IV x 1 dose 30 minutes prior to skin incision
Re-dose if procedure lasts > 4 hours or if patient loses > 1500 mL blood 3 g IV x 1 dose 30 minutes prior to skin incision
Re-dose if procedure lasts > 4 hours or if patient loses > 1500 mL blood
<1200g1200 to 2000g>2000gAge >28 DaysAge 0 to 4 weeks: 20 mg/kg/dose IV Q12HAge 0-7 days: 20 mg/kg/dose IV Q12H
Age >7 days: 20 mg/kg/dose IV Q12HAge 0-7 days: 20 mg/kg/dose IV Q12H
Age >7 days: 20 mg/kg/dose IV Q8HAll Infants: 20 mg/kg/dose IV Q8H
Age 0-7 DaysAge >7 Days30 mg/kg/dose IV Q12H x 4 doses30 mg/kg/dose IV Q8H x 6 doses
0 - 30 30 - 50 50+ 2 g IV q12 - 24h2 g IV q12h2 g IV q8h
Increase dosing interval in renal impairment
Susceptible Staphylococcal, Streptococcal and Gram negative infections.
Skin and soft tissue infection (i.e. cellulitis), bone and joint infections, endocarditis
Surgical prophylaxis including cesarean section prophylaxis.
Chorioamnionitis and endometritis (in combination with metronidazole)
Allergy (immediate or delayed).
Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.
Probenecid prolongs half-life. Drug interaction has been used therapeutically to give once daily cefazolin.
Cefazolin does not share any structural side chain similarities with any other beta lactam antibiotic including other cephalosporins.
Cefazolin should be avoided in patients with a direct allergy to cefazolin itself or a history of severe Type IV hypersensitivity reactions (ie. Stevens Johnson Syndrome) to any beta lactam.
