Infuse over 20 minutes
Age 0-4 wk50 mg/kg/dose IV Q12H
Age 0-7 days>7 days50 mg/kg/dose IV Q12H50 mg/kg/dose IV Q8H
Age 0-7 days>7 days50 mg/kg/dose IV Q12H50 mg/kg/dose IV Q8H
All Infants: 50 mg/kg/dose IV Q8H
IV, IM
100 mg/mL
Reconstitute 500mg vial with 5mL of sterile water for injection = 100 mg/mL
24H Refrigerate
0 - 30 eGFR30 - 50 eGFR50+ eGFR1 - 2 g IV q12 - 24h1 - 2 g IV q8 - 12h1 - 2 g IV q6 - 8h
Increase dosing interval in renal impairment
Empiric therapy for bacterial meningitis, pneumonia, intra-abdominal infection, musculoskeletal i.e. septic arthritis, and urinary tract infection.
Rash, localized phlebitis at injection site, allergy.
Positive Coombs test, neutropenia, abnormalities in liver enzymes.
Diarrhea and CDI.
Cefotaxime is the preferred 3rd generation cephalosporin vs ceftriaxone in pregnant patients near delivery (particularly preterm delivery) to minimize ceftriaxone exposure in the newborn.
