Infuse over 20 minutes
Age 0-4 wk50 mg/kg/dose IV Q12H
Age 0-7 daysAge >7 days50 mg/kg/dose IV Q12H50 mg/kg/dose IV Q8H
Age 0-7 daysAge >7 days50 mg/kg/dose IV Q12H50 mg/kg/dose IV Q8H
All Infants: 50 mg/kg/dose IV Q8H
IV, IM
100 mg/mL
Reconstitute 1g vial with 9.4mL of sterile water for injection = 100 mg/mL
24H Refrigerate
0 - 10 eGFR10 - 30 eGFR30 - 50 eGFR50+ eGFR2 g IV q48 - 72h2 g IV q24h2 g IV q12h2 g IV q8h
Increase dosing interval in renal impairment
Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.
Notable lack of gram positive activity versus other cephalosporins.
Allergy/rash (immediate or delayed)
Can cause positive Coombs, cytopenias, eosinophilia, and hepatic and renal laboratory abnormalities
