Pregnancy: Very limited data. Due to the known safety of other beta lactams in pregnancy, likely compatible.
Breastfeeding: Very limited data. Imipenem seems to transfer into breastmilk in very low amounts. In the information available currently, it does not appear cilastatin transfers into breastmilk in detectable amounts.
Immediate and delayed-type allergy
GI disturbance
Anemia
Cytopenias, positive Coombs
Liver enzyme abnormalities
CNS effects including confusional states and seizures
May decrease serum concentrations of valproic acid
Ganciclovir/valganciclovir - may increase risk of seizures
Cyclosporine - may enhance neurotoxic effects of imipenem
Non formulary
Cilastatin prevents renal metabolism of imipenem by competitive inhibition of dehydropeptidase along the brush border of the renal tubules.
