Piperacillin-Tazobactam

C difficile risk
Medium
Oral Bioavailability
N/A

Dosing

3.375 IV q6h

Severe Pseudomonas infections: 4.5 g IV q6h

IV

40 mg/mL in NS (Piperacillin)

Supplied by pharmacy

24H room temperature

0 - 30 eGFR30 - 50 eGFR50+ eGFR2.25 g IV q6 - 8h2.25 - 3.375 g IV q6hNo dosage adjustment required.

Extend dosing interval in infants with renal dysfunction. Consult NICU pharmacist for dosing recommendations

General Information

Broad spectrum agent with anti-pseudomonal activity used for severe infections including sepsis, pneumonia, intra-abdominal/hepatobiliary, UTI, polymicrobial skin and soft tissue infection, and febrile neutropenia.

Pregnancy: Compatible.

Breastfeeding: Compatible.

  • Scr (particularly if on other nephrotoxic agents ie. vancomycin)

  • CBC

  • Liver enzymes

  • Allergy/rash (immediate or delayed), cytopenias - esp. thrombocytopenia, eosinophilia, interstitial nephritis, abnormal liver enzymes, GI intolerance (diarrhea)

  • Can cause prolonged bleeding time, prolonged partial thromboplastin time, prolonged prothrombin time

Can increase the risk of nephrotoxicity when given with vancomycin.

Higher doses required for antipseudomonal coverage (4.5 g IV q6h)

Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor.