Valacyclovir
Renal

Renal

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

Not On Dialysis (eGFR)

<10 eGFR

500 mg po daily

10 - 30 eGFR

500 - 1000 mg po daily to BID

30+ eGFR

No dose adjustment required.