Antimicrobials
Oseltamivir (Tamiflu)

Oseltamivir (Tamiflu)

None
Excellent
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Spectrum of Activity

General Information

Treatment and prophylaxis of influenza

Rare

  • Stevens Johnson

Common

  • Nausea
  • Vomiting
  • Headache

Severe

  • Hypersensitivity
  • Neuropsychiatric

ECMO and CRRT generally do not affect the probability of target attainment with standard doses of oseltamivir. Because the elimination pathway for the active metabolite, oseltamivir carboxylate, relies heavily on tubular secretion, anuric patients receiving CRRT/ECMO experience a several-fold increase in drug concentration; thus, higher than standard doses are not necessary

Antimicrobial class: Neuraminidase inhibitor

Average serum half life: 2 hours

Lung penetration: Therapeutic