Urinary tract infections, susceptible MRSA infections, Stenotrophomonas infections, Pneumocystis jirovecii pneumonia (treatment or prophylaxis).
Laboratory
With high dose: consider baseline and periodic measurement of Cr (dose adjustment and nephrotoxicity assessment)
CBC
K
LFTs
Clinical
Hypersensitivity
GI effects
ACEi - increased serum potassium level
Increases amantadine levels
Decreases cyclosporine
Methotrexate - marrow suppression
Increases phenytoin
Increases rifampin
Increases INR with warfarin
Antimicrobial class: Sulfonamide - Antifolate
Average serum half life: 10 hours
Biliary penetration: Moderate
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic