Antimicrobials
Polymyxin B (Poly-Rx)

Polymyxin B (Poly-Rx)

Restricted

Medium
N/A
$$

Spectrum of Activity

General Information

  • Infections due to MDR Enterobactericiae, Acinetobacter, and Pseudomonas on a case-by-case bass.
  • Per UCLA Policy HS 1444, formal ID consultation is required for use of polymyxin B
  • Infections due to non-MDR pathogens for which alternate therapy, particularly beta-lactam antibiotics, are available
  • Prophylaxis

Severe infectious caused by multidrug-resistant Gram-negative organisms when other antimicrobial options are limited

Laboratory

  • BMP minimum of twice weekly

Clinical

  • Monitor for nephrotoxicity, neurotoxicity, neuromuscular blockade.
  • Nephrotoxicity
  • Neurotoxicity
  • Electrolyte abnormalities

May enhance the effect of other neuromuscular blocking agents

Infectious Diseases consultation required. Reserved for patients with a documented susceptible multi-drug resistant (MDR) organism or RECENT history of an MDR infection.