Antimicrobials
Isavuconazole (Cresemba)

Isavuconazole (Cresemba)

Restricted

Low
Excellent
$$$$

Spectrum of Activity

General Information

Infectious Diseases consultation required unless used as antifungal prophylaxis in patients with hematologic malignancies or undergoing transplant.

Invasive Aspergillus and Invasive Mucor

Laboratory

  •  CBC, CMP at start weekly, then may do periodically after

Clinical

  • Liver disfunction
  •  QTc changes
  •  Hypokalemia
  • GI upset
  • Elevated liver enzymes
  • Arrhythmias
  • QTc abnormalities
  • Hypokalemia
  • Cough
  • Peripheral edema
  • Peripheral neuropathy
  • CNS side effects
  • Renal failure

CYP3A4 Interactions - multiple

Avoid in patients with familial short QTc syndrome